Approaches to Assessing Drug Safety in the Discovery Phase Highlights of the Society for Medicines Research Symposium
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چکیده
The Society for Medicines Research symposium, sponsored by Apredica, Gwathmey Preclinical Services, Gentronix and Cyprotex, was held at the National Heart and Lung Institute, Kensington, London, U.K. The meeting, organized by Jack Allen, Phil Jeffrey and Andrew Ratcliffe, focused on approaches to assessing drug safety in the discovery phase. Topics included molecular aspects of adverse drug reactions from molecule to man, the relationship of physicochemical properties to toxicity, reactive metabolites, inhibition of the cardiac sodium channel, drug-induced mitochondrial dysfunction, high-throughput screening for genotoxicity and carcinogenicity, and the use of zebrafish as a model for hepatotoxicity and developmental toxicity.
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تاریخ انتشار 2010